Since we only had accurate estimates for height, BMI, EduYears, and self-rated health, we focused on these four phenotypes. For these traits, we computed sample-size-weighted average CGR estimates across the pairs of studies. Table 2 shows the number of hits and PGS R2 reported in the most comprehensive GWAS efforts to date for the traits of interest, together with predictions from the MetaGAP calculator. We tried several values for the number of independent haplotype blocks (i.e., 100k, 150k, 200k, 250k) and for the number of trait-associated blocks (i.e., 10k, 15k, 20k, 25k). Overall, 250k blocks of which 20k trait-affecting yielded theoretical predictions in best agreement with the empirical observations; we acknowledge the potential for some overfitting (i.e., two free parameters set on the basis of 17 data points; 10 data points for the reported number of hits and 7 for PGS R2).
