While cMAGMA gave a similar result to H-MAGMA, there were important discrepancies, which include astrocytic expression of ASD-associated genes, lack of astrocytic expression of PD- and ALS-associated genes, and lack of endothelial expression of MS-associated genes (Extended Data Fig. 4). Given the growing evidence of astrocyte-mediated neurodegeneration in ALS and PD33,34, the emerging role of blood-brain barrier in MS35, and lack of genetic association signals of an astrocytic co-expression network in ASD36, this result indicates that H-MAGMA can provide cellular etiology that can be missed by cMAGMA.
