As we detected a remarkable cellular specificity for both psychiatric and degenerative disorders, we next sought to identify disorder risk genes in a cell-type specific manner. To this end, we built H-MAGMA framework based on Hi-C interactions from iPSC-derived neurons and astrocytes37. Neuronal and astrocytic H-MAGMA were subsequently used to decode psychiatric and degenerative disorder GWAS, respectively (Fig. 3a). We found that a significant proportion of genes (20–40%) were detected in a cell-type specific fashion (Extended Data Fig. 5).
