Cell-type specific H-MAGMA recapitulated biological processes, cell-type specificities, and developmental trajectories of brain homogenate H-MAGMA. For example, brain disorder risk genes derived from cell-type specific H-MAGMA were involved in transcriptional regulation, neurogenesis, and synaptic transmission (Supplementary Data 6). Degenerative disorder risk genes showed pronounced enrichment for glial development and inflammatory responses.
