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Chunk #21 — Illustrative evidence: MAOA, 5-HTTLPR, dopamine receptor D4 (DRD4) — The 5-hydroxytryptamine-linked polymorphic region polymorphism

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Vulnerability genes or plasticity genes?
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yes

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negative life events, consistent with a diathesis–stress framework, yet the fewest symptoms when they experienced a supportive early environment or recent positive experiences, that is—and importantly—not just the absence of adversity. A similar for-better-and-for-worse pattern of environmental effects emerged in still other investigations of stressful life events and depression, including one targeting depressed patients, healthy controls and experiences during the 6 months before study enrollment,25 and another of a sizeable community sample (n=567) and life events up to 2 years before the assessment of depression.26