The three-way interaction results were very similar in the subsample that did not include probands with alcohol dependence (n = 1,996). The difference in predicted probabilities of alcohol dependence associated with genotype for men was 0.22 at 0 uplifts (Z = 2.47, p < 0.01) and 0.14 at 2 uplifts (Z = 3.32, p < 0.01), but never achieved statistical significance for women. The figure of predicted probabilities looked nearly identical to the one presented here except for a modest intercept shift associated with removing a substantial proportion of respondents with alcohol dependence from the sample (available upon request).
