This study aimed to replicate the findings of Moyer et al (2011), who found rs1076560 to be associated with cocaine abuse in a mixed population of AA and EA individuals (N=214). They found the minor allele of rs1076560 to have a frequency of 18% in cases and 10% in controls. We did not find rs1076560 to be associated with cocaine dependence in either EA or AA populations; however, we did observe the same trend as the minor allele was increased in cases compared to controls. However, rs1076560 was found to be associated with opioid dependence in both the EA and AA populations. In the EA population the MAF in cases compared to controls was 17% vs 14% and in the AA population the MAF was 12% in cases and 9% in controls. The odds ratios associated with these findings are relatively modest: 1.27 for EA opioid dependence and 1.43 in AA opioid dependence.
