As the association analyses involving the opioid dependent samples yielded statistically significant results for both EA and AA, these samples were combined (n=2578) and a logistic regression analysis was performed. In the regression model, ethnicity was used as a covariate since the minor allele frequency of the SNP in the two populations was different (14% EA vs 9% AA). A significant association was found between opioid dependence and rs1076560 (p=0.0038, OR=1.29) (Table 3). This association remained significant after correction for multiple testing (FDR p=0.034).
