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Chunk #13 — RESULTS

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The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction.
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Genotypic tests for association revealed a nominal association of rs1076560 in the EA opioid population (χ2=6.15, 2 d.f., p=0.046); however, the genotypic association in the AA opioid population only displayed a trend towards significance (2 d.f, p=0.051, Fisher's Exact test) (Table 2). Genotypic tests for association did not reveal significant associations for either cocaine population (data not shown). All association statistics and observed allele frequencies are summarized in Table 1. After correction for multiple testing none of the associations of rs1076560 with opioid dependence remained significant (FDR p<0.06).