The CHRND gene contains one SNP significant after multiple test correction. This SNP, rs12466358 (p = 0.00027), is a singleton bin in our data, although other SNPs have r2 ≥ 0.6 (but less than 0.8) with it (Figure 3C). It is noteworthy that the next most significant SNP in the CHRND-CHRNG cluster, rs1881492 (p = 0.00069) is uncorrelated with rs12466358 (r2 = 0.086), suggesting that there is a second distinct risk allele in this gene cluster, although this second signal does not meet our multiple test correction criterion.
