The CHRNB3-CHRNA6 gene cluster on chromosome 8 contains eight SNPs surpassing the multiple test criterion. These constitute a single r2 bin and a single association signal after LD is taken into account: rs13277254 is in nearly perfect LD with the other SNPs (Figure 3B), with each pairwise r2 exceeding 0.99. Even after the increased CIDR SNP coverage of this gene cluster, all significant SNPs are in the same LD bin as the previous associated SNPs we reported in (Saccone et al., 2007a), and no new distinct signals emerged.
