structural MRI in OCD is the lack of involvement of the prefrontal regions; this may reflect differences in methods used: The atlas‐based approach to cortical thickness and surface areas that has been used in ENIGMA (segmenting whole structures using coarse parcellation) can be less sensitive to subtle regional abnormalities than VBM's voxel‐wise registration and vertex‐based approach to cortical thickness that was used by OBIC. The use of higher‐resolution parcellation methods (e.g., Glasser et al., 2016) might give results that are more consistent with the voxel‐wise and vertex‐wise approaches.
