Reactome, microRNAs/gene targets and gene sets created from position weight matrices. In addition, we note that MSigDB contains chemical and genetic perturbation gene sets manually curated from supporting materials of publications, whereas Enrichr contains differentially expressed genes after chemical and genetic perturbation curated from GEO. We compared the GEO data sets covered by Enrichr and MSigDB and found that there is some overlap while Enrichr has coverage of more data sets (Figure 3B).