There are many other gene set enrichment analysis tools that could be compared with Enrichr; for example, some leading tools are Fidea (39), DAVID (13), WebGestalt (12), g:Profiler (12) and GSEA (40). The advantages of Enrichr over some of these tools are its comprehensiveness, ease of use and interactive visualization of the results. Enrichr is lacking some of the flexibility available with those other tools. For example, Enrichr merges human, mouse and rat genes, which has advantages and disadvantages. Enrichr does not have an ID conversion tool, which is highly desired by many users. Enrichr also does not have the ability to upload a background list, and it does not have implementation of parametric tests such as Gene Set Enrichment Analysis (GSEA) (40), Parametric Analysis of Gene set Enrichment (PAGE) (9), and our own Principal Angle Enrichment Analysis (PAEA) (41). These features are planned.
