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Chunk #28 — Results — BEHAVIORAL EFFECTS OF rhCRH -2232 C>G — Infant Behavioral Dimensions

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CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.
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Principal component extraction, followed by standard Varimax normalized rotation, identified three orthogonal factors with Eigenvalues >1.0 which, together, explained 73.0% of the variance (Table 1). These were labeled as “Anxious”, “Exploratory/Bold” and “Attached” 34. Animals with the C/G genotype rated higher on the “Exploratory/Bold” dimension (Figure 4A, F(1, 93)=6.6, P =0.01) than did those homozygous for the C allele, with genotype accounting for 7% of the total variance of this trait. In contrast, the other behavioral dimensions were not influenced by genotype (n.s.).