Among adolescent/young adult animals, those with the rhCRH -2232 C/G genotype (H2) had lower CSF levels of CRH (Figure 3A, F(1,70) = 4.7, P < 0.04) and higher plasma levels of ACTH (Figure 3B, F(1,138) = 7.96, P = 0.005), with genotype accounting for 6–7% of the variance. Cortisol levels did not differ according to genotype (n.s., data not shown). These findings were the same after controlling for differences in early stress exposure (i.e., rearing condition).
