In contrast to broad chromosomal alterations, focal SCNA events occurred at greater frequency in doubled genomes (Fig. 6e). Consistent with previous reports 35, 40, 41, the observed frequency of focal SCNAs as a function of their length (L) followed power-law scaling: P(L) ∝ L−α, for L > 0.5 Mb (Fig. 6e). Genome doubling was associated with a larger overall number of SCNAs, however we obtained estimates of α near 1 for each group (Fig. 6e), suggesting that the mechanism(s) by which they were generated did not greatly depend on ploidy.
