We next sought to correlate whole-genome doubling occurrence in ovarian carcinoma with other genetic and clinical features. Genome-doubled samples showed a higher incidence of heterozygous mutations, but correcting for sample ploidy removed this effect (Fig. 7a), suggesting that the per-base mutation rates are equivalent. Clonal mutations at multiplicity > 1 were approximately ten-fold more prevalent in doubled samples; many of these events likely occurred prior to the doubling event. Genome-doubled samples had a lower frequency of homozygous deletions (Fig. 7b) and a two-fold lower rate of clonal homozygous mutations (P = 1.55×10-8, Fig. 7c). We expect that many of the observed homozygous alterations in the doubled samples were fixed prior to genome doubling.
