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Chunk #21 — Results — Primary self-administration outcomes

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Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.
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Overall, participants achieved a mean peak BrAC of 81.18 mg% (SD=24.96). Sex differences were not significant (males: M=87.52 mg%, SD=22.62, females: M=74.16mg%, SD=26.12, F [1,38] = 3.00, p = .09). Estimated AUC values (reflecting cumulative alcohol exposure during the ad libitum phase in mg% * minutes), averaged 6307.37 (SD=2228.19) and did not differ significantly by sex (males: M=6864.76, SD=2058.69; females: M=5691.31, SD=2298.90, F [1,38] = 2.90, p = .10). Over half of participants (57.5%) surpassed the 80mg% threshold defining a heavy episode, including 66.7% of males and 47.4% of females, χ2[1]= 1.52, p = .22).