The mean time course of model-projected aBAC by genotype is shown in Figure 2. There was a significant association of OPRM1 with peak BrAC, with GA/GG participants achieving higher BrAC (M=94.90 mg%, SD=16.56) than AA participants (M=74.46 mg%, SD=25.36) (F [1,36] = 5.59, p = .02). Consistent with this finding, a supplemental analysis showed significantly more post-priming drink requests by GA/GG participants (M=16.90, SD=4.27) versus AA participants (M=13.14, SD=4.21, F [1,36] = 6.57, p = .02). Mean AUC estimates by genotype were 7212.02 (SD=1967.41) for GA/GG participants and 5827.82 (SD=2228.20) for AA participants (F [1,36] = 3.00, p = .09). Most GA/GG participants (80%) surpassed the 80mg% threshold, compared with 46% of AA participants (χ2[1] = 3.36, p = .07).
