these analyses, remission was characterized as non-abstinent or abstinent (no alcohol consumption for 12 months), based on the most recent information about AUD symptoms and alcohol consumption. The AUD/remission status for probands and for relatives who participated in the follow-up was based on their 5-year follow-up. For relatives with only one interview, AUD/remission status was based on recency of AUD symptoms at the time of interview.