We repeated these polygenic risk score analyses in a subset of adolescents/young adults from the COGA sample. Results from this replication are shown in Table 3, with the top panel indicating the set of analyses in which the COGA young adults made up the validation sample for GWAS and score weighting, and the bottom panel indicating the analyses in which they were the discovery sample for score prediction. There were no statistically significant associations between polygenic scores and AUDs in this set of analyses. The pattern of association (negative across sample type, positive within sample type, at nominal significance levels) was the same as in the full COGA sample.
