Chunk #54 — Materials and Methods — Enrichment analysis of trait-associated SNPs and SNPs located within the HLA region

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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

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For the MHC enrichment analysis the followed procedure was identical, with the difference that we looked for enrichment for SNPs within the MHC, defined as SNPs physically mapping between 20 Mb and 40 Mb on chromosome 6 (NCBI 36 assembly).