Chunk #55 — Materials and Methods — Trans-eQTL replication datasets

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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

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Replication of the detected eQTLs was performed in monocytes from 1,490 different samples [45] and in an independent population of 86 morbidly obese individuals that underwent elective bariatric surgery (Department of general surgery, Maastricht University Medical Centre, the Netherlands). Both these datasets also used the same Illumina HumanHT-12 expression platform.