Chunk #56 — Materials and Methods — Trans-eQTL replication datasets

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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

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For the 1,490 monocyte samples eQTL P-Values summary statistics were available for all monocyte trans-eQTLs with a nominal p<1.0×10−5. We ascertained how many of the trans-eQTLs we had found in our peripheral blood data had a nominal eQTL p<1.0×10−5 in this monocyte dataset.