UKB13 is a population-based health research resource consisting of approximately 500,000 people, aged between 40 and 69 years, who were recruited between the years 2006 and 2010 from across the UK14. Of these, 152,729 individuals were included in the first genotype data release. In the current study we restricted the sample to individuals of white British ancestry. Participants who were also in GS:SFHS, their relatives and relatives of remaining UKB participants (relatives: up to and including third degree) were identified by a kinship coefficient ≥ 0.0442, using the KING toolset18, and subsequently excluded (n = 7 698). Depression case/control status was assessed in 172,751 of the 500,000 individuals using a self-diagnosed touchscreen questionnaire. Case status was defined as either “probable single lifetime episode of major depression” or “probable recurrent major depression (moderate and severe)”. Control status was defined as “no mood disorder”, as described by Smith et al17. 149,847 individuals had sufficient data to allow an assessment of case/control status. Individuals with probable bipolar disorder (n = 1 615) or mild depressive/manic symptoms (n = 26 847) were excluded. After
