mood disorder”, as described by Smith et al17. 149,847 individuals had sufficient data to allow an assessment of case/control status. Individuals with probable bipolar disorder (n = 1 615) or mild depressive/manic symptoms (n = 26 847) were excluded. After exclusions outlined above, this resulted in 8248 depression cases (of which 6056 were recurrent) and 16,089 controls. Stratification by sex resulted in 5138 female cases, 7013 female controls, 3110 male cases and 9076 male controls. Further information on sample collection, genotyping and assessment of the depression phenotype in GS:SFHS and UKB are provided in the Supplementary Methods.
