episode), antidepressant use within the last six months and lifetime antidepressant use of more than one year. Subjects were required to stop drinking 24 hours prior and pass a breathalyzer prior to participation. Individuals with excessive motion (>2 mm translational or 0.035 radians rotational movement, n=39 ALC, n=10 HC) or technical problems (wrong acquisition plane, n=1 ALC) were excluded. The final full ALC sample included 383 subjects with the following comorbid substance use within the past 60 days (No/Yes/Unknown): Cigarettes, 105/278; Marijuana, 213/146/24; Other Substances, 326/33/24 (cocaine – 11; methamphetamine – 3; hallucinogens – 5; opiates – 3; two or more of these substances – 11). Written informed consent, approved by the University of New Mexico Human Research Committee, was obtained from all participants.
