The survival map and Kaplan-Meier curve were generated from Gene Expression Profiling and Interactive Analyses vision 2 (GEPIA2).4 The OS or DFS analysis was based on gene expression and survival time; the median was selected as the threshold for splitting the high-expression and low-expression cohorts (Cut-off = 50%); the HR based on Cox proportional hazards Model were calculated; P-value < 0.05 was considered statistically significant using the log-rank test.