The Lung Cancer Explorer (LCE) (Cai et al., 2019) is an open access web resource, which collects data from 56 lung cancer studies that include over 6700 patients. In this study, LCE was employed to evaluate the prognostic value of ZDHHC5 and INCENP using meta-analysis. Forest plots generated by the LCE meta-analysis module indicate heterogeneity test using the I2 statistic, which refers to the percentage of variation across datasets that is due to heterogeneity. All data was obtained from 19 independent LUAD studies from GEO and TCGA, listed as Tomida_2009 (GSE13213), Hou_2010 (GSE19188), Wikerson_2012 (GSE17710), Staaf_2012 (GSE29016), Kuner_2009 (GSE10245), Rousseaux_2013 (GSE30219), Okayama_2012 (GSE31210), Bild_2006 (GSE3141), Girard_N_c (GSE31548), Botling_2013 (GSE37745), Jones_2004 (GSE1037), Sato_2013 (GSE41271), Tang_2013 (GSE42127), Der_2014 (GSE50081), Schabath_2016 (GSE72094), Zhu_2010 (GSE14814), Takeuchi_2006 (GSE11969), Shedden_2008 (Consortium) (Shedden et al., 2008), and TCGA_LUAD_2016. In this study, I2 = 45% (ZDHHC5) and 54% (INCENP), which indicates intermediate different heterogeneity of LUAD datasets.
