In order to confirm that the enrichment signal is not dependent on the domain with the strongest standardized loadings onto the wave-specific externalizing factors (cannabis, Table 1) or on the domain of primary interest to the consortium that assembled the gene set (alcohol), we performed a series of sensitivity tests by removing each of these two measures from the analysis. We re-fit the hierarchical factor model with either all cannabis-related measures removed or all alcohol indicators removed, and re-ran the enrichment analyses on these new sets of factor score estimates. Despite the absence of either cannabis or alcohol measures, the enrichment signal persisted at or above the permutation threshold (Supplemental Tables S2–S3). Thus, it is clear that this signal does not depend on the presence of either cannabis or alcohol measures in the model.
