EEG studies are confronted with two major methodological problems. First is the management of the abundant artifacts observed in young and behaviorally difficult to manage children (for example, eye movement, eye blink and muscle activity). It has been well established that even EEGs appearing clean by visual inspection may contain significant artifacts [38,39]. Moreover, as shown in schizophrenia EEG research, certain artifacts may be group specific [40]. Second is the capitalization upon chance, that is, application of statistical tests to too many variables and incorrect reports of those that appear significant by chance as support for the experimental hypothesis [41]. Methods discussed below were designed to specifically address these problems.
