ADH1B rs1693457 genome-wide significant association, the variants with relevant effects are mainly located within METAP1 and ADH1B haplotypes. For the ADH1C rs6846835 genome-wide significant association, most variants with relevant effects are located in METAP1 and ADH1C haplotypes, and they showed relevant effects also on ADH1B association. In CEU, the PDLIM5 gene region includes eight haplotype blocks, and the genome-wide significant variant is located in last (i.e., 3′-most) haplotype block (i.e., Block 8). Most variants with significant effects on the genome-wide association are located in Block 1 and Block 2; single haplotypes are present for each of the remaining genes (i.e., METAP1, ADH1B and ADH1C). The variants with relevant effects on the ADH1B rs1693457 genome-wide significant association are mainly located in METAP1 and ADH1B haplotypes, while the relevant findings related to ADH1C rs6846835 genome-wide association are located in an ADH1C haplotype and most of them showed significant effects also on the ADH1B rs1693457 genome-wide association.
