Considering the PDLIM5, ADH1B and ADH1C analyses, we observed that the most significant findings are related to common functional alleles with high African or European ΔFs located in the regions surrounding genome-wide significant variants. To analyze the local haplotype structure of the PDLIM5-ADH1B-ADH1C region (chr4:95,379,741- 100,274,157), we used 1KG Phase 1 data from the ASW populations to investigate AAs and from the CEU to investigate EAs, considering those ancestry variants with relevant effects on PDLIM5 rs10031423, ADH1B rs1693457 and ADH1C rs6846835 associations with AD outcomes. In accordance with the method of Gabriel and colleagues [36], we observed 14 and 11 haplotype blocks in ASW and CEU, respectively (Supplementary Figures 8 & 9). In ASW, PDLIM5 included ten haplotype blocks. The ancestry variants with effects on PDLIM5 genome-wide significant association are located in the haplotype blocks closer to rs10031423. Regarding the ADH1B rs1693457 genome-wide significant association, the variants with relevant effects are mainly located within METAP1 and ADH1B haplotypes. For the ADH1C rs6846835 genome-wide significant association, most variants with relevant effects are located in METAP1 and ADH1C haplotypes, and they showed
