in both ancestry groups for the association between ADH1C rs6846835 and AD symptom count (Supplementary Table 12). Regarding the analysis of ADH1C rs6846835 in EAs, we observed 72 variants with significant z-scores. They are all located on chromosome 4 (Supplementary Table 13). Among these variants, only rs4147541 showed evidence of regulatory function (RegulomeDB score = 3a, i.e., TF binding + any motif + DNase peak) and an effect that increased the association significance of ADH1C rs6846835 with AD symptom counts in EAs (z = 39.468; meta-analyzed p-value from 0.950 to 0.041).
