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Chunk #41 — 4. Experimental procedures — 4.6 ERO, PLI, and PDLI analyses

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Ethanol reduces the phase locking of neural activity in human and rodent brain.
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Rectangular regions of interest (ROIs) were defined within the time-frequency analysis plane by specifying, for each ROI, a band of frequencies and a time interval relative to the stimulus onset time. Time 0 in these definitions is the onset of the stimulus. The ROI frequencies in both human and animal studies were: delta (1-4 Hz), theta (4-7 Hz), alpha (7-13 Hz), beta (13-30 Hz) and gamma (30-50 Hz). The ROI time intervals were delta (200-500 ms), theta (10-400 ms), alpha (0-300 ms) beta (0-300 ms) gamma (0-300ms) ROI time intervals were selected based on ERO energy in specific ERP component locations (N1, P3) in previous ERP studies (Ehlers et al., 1998a). Using mean values over trials, for each of S transform energy (square of magnitude), PLI amplitude, and PDLI amplitude, the maximum value and its location in frequency and latency (time with respect to onset of stimulus) were calculated for each ROI, for each electrode location or, for PDLI, for each pair of electrode locations.