not lead to any significant bias towards SNPs on Metabochip (data not shown). We forced in 62 of the GWS loci in Table 1, so all of the 97 SNPs were among the 590 SNPs. The 590 SNPs were further merged into 511 non-overlapping regions (FDR < 0.05) used in DEPICT analysis. For additional information on the analysis please refer to Supplementary Methods.