To explore the relationship between BMI and an array of cardiometabolic traits and diseases, association results for the 97 BMI index SNPs were requested from 13 GWAS meta-analysis consortia: DIAGRAM (type 2 diabetes)56, CARDIoGRAM-C4D (CAD)57, ICBP (systolic and diastolic blood pressure (SBP, DBP))58, GIANT (waist-to-hip ratio, hip circumference, and waist circumference, each unadjusted and adjusted for BMI)13,59, GLGC (HDL, low density lipoprotein cholesterol, triglycerides, and total cholesterol)60, MAGIC (fasting glucose, fasting insulin, fasting insulin adjusted for BMI, and two-hour glucose)61–63, ADIPOGen (BMI-adjusted adiponectin)64, CKDgen (urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate, and overall CKD)65,66, ReproGen (age at menarche, age at menopause)67,68, GENIE (diabetic nephropathy)69,70. Proxies (r2 > 0.8 in CEU) were used when an index SNP was unavailable.
