One SNP, rs11035102, which is located in a region of several olfactory genes, showed genome-wide significant association with having a persistent desire to cut down/inability to do so criteria for AD, with strong support from several imputed SNPs in high LD (Figure 3B). This SNP was also moderately associated with the criterion of drinking alcohol despite physical/psychological consequences in the present study and with the total number of DSM-IV criteria (symptom count) in the same COGA family sample (p=3.8 × 10−5, Wang et al., 2012; Supplemental Table 2). This gene is near two olfactory receptors (OR52E2, OR52J3, seen in Figure 3B) shown previously to be significantly associated with number of cigarettes smoked per day in a pathway analysis across three independent cohorts ascertained on nicotine or AD, one of which was the COGA sample (Harari et al., 2012). In a study of opioid-dependent individuals, the desire/inability to cut down was found to be one of the most prevalent substance use disorder criteria across five substances of abuse, including alcohol (Wu et al., 2012). Although this was not the most prevalent
