SNPs with a p-value < 0.001 in the meta-analyses of AD (N=515 SNPs) and ND (N=386) were selected. Of these, 261 AD and 213 ND SNPs were located in or close to (<10,000 bp) 200 and 165 genes respectively. In total, 169 AD and 143 ND genes/gene-products were found in the IPA database (Ingenuity Systems, release IPA6.0). The Ingenuity database contains information about structure, biological function and subcellular localization of proteins as well as information about protein-protein interactions. The available information was summarized in a connectivity diagram and the gene-products were manually reorganized by grouping the proteins with related structure or function.
