1,672 SNPs that exceeded the genome-wide threshold for significance (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$P < 5{\times 10}^{-8}$$\end{document}P<5×10−8; Manhattan plot in Fig. 1, regional association plots and forest plots in Supplementary Figs. 2–31 and a list of all independent genome-wide significant SNPs in Table 1 with additional details in Supplementary Tables 2 and 3). The independence of the 30 lead SNPs was subsequently validated using conditional and joint analysis (GCTA-COJO)14 (Supplementary Table 4). Analysis of the X chromosome, conducted in a subset of the data for which this information was available (23andMe), yielded no significant associations (Supplementary Note 4 and Supplementary Fig. 37e). Of the 15 genome-wide significant loci previously reported in preprints12,13, 13 were genome-wide significant in the current GWAS, with the remaining two showing suggestive significance (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$P=5.23{\times 10}^{-8}\,{\rm{and}}\,{P}=2.2{\times 10}^{-7}$$\end{document}P=5.23×10−8andP=2.2×10−7; Supplementary Table 5). Using MiXeR15, we estimated that approximately 11,500 (standard error of the effect estimate (s.e.) = 607) causal variants account for 90% of the OCD SNP-based heritability.Table 1Genome-wide-significant loci associated with OCDSNPPositionP valueORs.e.A1/A2FRQCAFRQCOINFOn genesSelection of other significant traitsrs78587207a11q12.15.28 × 10−120.95220.0071T/G0.6810.6770.98711SCZ, well-being, neuroticism, educational attainmentrs132625958q24.31.31 × 10−110.95660.0066G/A0.5520.5610.9892SCZ, well-being, neuroticism, educational attainmentrs4990036a6p21.331.45 × 10−110.92990.0108T/C0.1190.1230.985118SCZ, depression, blood
