(s.e.) = 607) causal variants account for 90% of the OCD SNP-based heritability.Table 1Genome-wide-significant loci associated with OCDSNPPositionP valueORs.e.A1/A2FRQCAFRQCOINFOn genesSelection of other significant traitsrs78587207a11q12.15.28 × 10−120.95220.0071T/G0.6810.6770.98711SCZ, well-being, neuroticism, educational attainmentrs132625958q24.31.31 × 10−110.95660.0066G/A0.5520.5610.9892SCZ, well-being, neuroticism, educational attainmentrs4990036a6p21.331.45 × 10−110.92990.0108T/C0.1190.1230.985118SCZ, depression, blood cell count, lung functionrs10877425a12q14.11.62 × 10−110.95260.0072G/A0.5130.5160.9850–rs7626445a3p21.311.74 × 10−110.95510.0068T/C0.6470.6540.99432Neuroticism, smoking, blood cell count, heightrs2564930a3p21.13.41 × 10−110.95460.007T/C0.3390.3450.98812SCZ, neuroticism, blood cell count, BMIrs4702a15q26.19.07 × 10−101.04140.0066G/A0.4550.4490.9845SCZ, BP, MDD, risk-taking behaviorrs35518360a4q241.39 × 10−91.07570.0121T/A0.08280.07560.9471SCZ, neuroticism, educational attainment, BMIrs490473814q21.11.48 × 10−90.96050.0067T/C0.5580.5530.9841MDDrs2547795q14.31.53 × 10−90.96060.0067T/C0.4190.4210.9884Educational attainment, cognition, fat massrs2198140a8p122.18 × 10−90.95900.007T/C0.4960.5130.9791Cognitionrs12516488a5p123.79 × 10−91.05310.0088G/A0.8250.8260.9941Neuroticism, age at first birth, age at first sexual intercoursers3899258a5q11.14.94 × 10−91.05090.0085G/A0.7820.7920.9892–rs302716017p13.15.35 × 10−91.04970.0083T/C0.7750.7820.99619Sleep, heightrs2037682q33.16.14 × 10−90.95130.0086T/C0.8240.8170.9925SCZrs112639401p34.37.23 × 10−90.95780.0074T/C0.6890.690.9910Neuroticism, well-beingrs67839857a5q14.37.63 × 10−91.04230.0072G/A0.6920.6910.9940–rs155546620p11.238.42 × 10−91.04900.0083T/C0.2180.2240.9960Ease of skin tanningrs98861117q21.138.59 × 10−90.95980.0071G/C0.7010.7110.9922–rs92878592q24.39.83 × 10−90.95950.0072G/A0.390.390.9941–rs20873194q121.59 × 10−80.95790.0076C/A0.740.7440.9686Height, blood pressurers11125759a2p16.11.79 × 10−80.96900.0071G/A0.5690.5560.9911BMI, sleeprs64746289p231.89 × 10−81.03800.0066T/G0.5790.5850.9990–rs117682387q332.28 × 10−80.96010.0073G/A0.6610.6610.9982Educational attainment, age at first sexual intercoursers94791386q25.12.41 × 10−81.03970.007T/G0.3390.340.9751Educational attainment, age at first sexual intercourse, age at first birth, lung functionrs15672884q22.33.80 × 10−80.96430.0066G/A0.5480.550.9811–rs48311303q13.313.93 × 10−81.04270.0076T/G0.7530.740.9842–rs177184443p134.25 × 10−80.96220.007T/C0.3230.320.9842Educational attainment, lung function, use of sun/UV protectionrs6660196a1q24.14.86 × 10−81.04030.0072T/G0.6380.6420.9891Blood cell countrs493120q13.125.00 × 10−80.96090.0073C/A0.2780.2790.9935Blood cell count, height, BMIShown are the lead SNP, the chromosome, base pair position on the genome, P value, effect estimate as an odds ratio (OR), s.e., effect allele and non-effect allele (A1 and A2), frequency of
