uncertainty is taken into account in the meta-analysis procedure. SNPs have been excluded from analysis if MAF was less than 1% in any dataset or if imputation r2 was less than 0.3. This threshold was used in four previous large meta-analyses because it removed most poorly-imputed SNPs but few well-imputed SNPs.34–37 The meta-analysis included 2,391,203 SNPs (2,339,408 autosomal and 51,795 X chromosome SNPs).
