Chunk #23 — Materials and Methods — STATISTICAL ANALYSES — — Analysis of genetic association

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Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.

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For each dataset, separate association analyses were carried out for Broad and Narrow phenotypes (all GenRED cases were Narrow) for all subjects and then for males and for females separately. The a priori primary analyses (for STAR*D and for the meta-analysis) considered the Broad phenotype for all subjects. For STAR*D, the primary analysis was limited to genotyped SNPs; for the meta-analysis it included genotyped plus imputed SNPs.