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Chunk #24 — DISCUSSION

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Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.
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These analyses revealed several genome-wide significant (GWS) associations with PTSD visible at the case-control level, and numerous GWS associations with various dimensions of symptom severity. When combined with imputed genetically regulated expression results and enrichment analyses, these results help to illuminate the neurobiology of PTSD and begin to uncover new avenues for therapeutic development.