The past decade has seen a proliferation in the use and usefulness of GWAS, with the prediction – and, to date, the experience – that continued sample size growth will result in even richer findings45. The field of psychiatric genomics has capitalized on GWAS, with substantial gains made in the understanding of serious mental disorders such as schizophrenia, major depression, bipolar disorder7,46, and their interrelatedness47. We present here a large, uniformly phenotyped and genotyped case-control GWAS of PTSD in military veterans. We augment this analysis with the GWAS of a quantitative trait corresponding to symptom severity, which proved more genetically informative than the case-control analysis even when our case-control GWAS was meta-analyzed with the next largest PTSD case-control GWAS available, from the PGC13.
