We examined whether any of the most highly associated SNPs (from Table 2) were located in the linkage regions implicated in the two previous genome-wide scans focused on CD symptomatology (among samples originally ascertained for alcohol dependence, as in this report), in the COGA and IASPSAD samples. Peaks in the IASPSAD sample for CD symptoms were reported with markers located on chromosomes 1, 2, 7, 8, 10 and 14,39 and in COGA on chromosomes 1, 2, 3, 12 and 19 for CD diagnoses and symptom counts.40 One of the associated SNPs from the CD analyses reported in this study, rs13398848, was located in a region on chromosome 2 with converging evidence of linkage across the two samples. The SNP is located B2MB from the peak marker in the COGA scan (D2S1331), and < 8MB from the peak marker from the IASPSAD scan (D2S2116). The SNP is intergenic; however, the closest gene downstream is CTNNA2 (Catenin, -2), located B4MB away. CTNNA2 is an interesting candidate, as it is considered to be involved in stability of synaptic contacts,41 and disruption of the
