IASPSAD scan (D2S2116). The SNP is intergenic; however, the closest gene downstream is CTNNA2 (Catenin, -2), located B4MB away. CTNNA2 is an interesting candidate, as it is considered to be involved in stability of synaptic contacts,41 and disruption of the gene in mice has been associated with fear conditioning and prepulse inhibition of the startle response.42 Dysregulation of inhibitory responses is considered to be related to the development of conduct problems and antisocial behavior (as well as drug dependence).43 Two additional SNPs on chromosome 10 showing evidence of association in the GWAS, rs2419006 and rs2184898, were located 1 and 4 MB, respectively, from markers yielding significant evidence of linkage (D10S597 and D10S1679) in the IASPSAD sample. These SNPs were also intergenic. None of the other top SNPs from Table 2 were located within 10MB of peak markers from the linkage scans.
