We took advantage of a dataset of 220 modern Ethiopians and Egyptians jointly called with a subset of the 1000 Genomes Project26 from Pagani et al.25, adding African-Americans belonging to the “ASW” population from 1000 Genomes Project26, and adding other modern populations from the 1kg project as reference : “CEU”, “IBS”, “TSI”, “YRI”, “LWK”, “CHB”. All Ethiopians with the exception of Gumuz were merged and labeled as “ETHIOPIA”. To test pPS predictivity we relied on two different datasets, one extracted from UK Biobank27,accessed under Project #17085, and one extracted from Estonian Biobank31, accessed with Approval Number 285/T-13 obtained on 17/09/2018 by the University of Tartu Ethics Committee.
