In the discovery phase, association results of 235 677 single-nucleotide variants (SNVs) from 104 452 individuals were meta-analysed using a fixed-effects model (Supplementary Material, Fig. S1). Two analyses were performed. The first used RR-intervals (RR in milliseconds= 60 000/HR, in beats per minute, according to the inverse relationship between HR and RR). The second used the inverse-normalized residuals of the linear regression RR-interval adjusted for age + sex + body mass index (BMI) as covariates (denoted as RR-INVN). An overview of the study design is provided in Figure 1.
